She was also seen in many commercials for reputed brands like Nirma, Lifebuoy, Hair and Care and others. She has played lead roles in the serial Kahin To Milenge, in which she portrayed the character of Tanisha, the rich and pampered girl with a heart of gold. Then she also appeared in another soap Koi Dil Mein Hain in which her character of Kruttika saw a major transformation from a sweet and innocent girl who would do anything for her best friend to a negative one who also plotted the murder of her best friend's husband. In the most popular tele-serial 'Kyunki' she enacts the role of Indu who is a dumb girl, a chatterbox but with an impish charm. She is always talking and is a source of comic relief in any tense situation. She shares a strong liking for hunks and is always running after boys.
Karishma Tanna also made a hurried entry into Bollywood movie Dosti-Friends Forever which had popular star cast including Bobby Deol and Akshay Kumar. In this movie she had played a cameo. She enacted the role of Bobby Deol's sister in this film. Presently Karishma Tanna is doing a lot of fashion shows, anchoring and other stuffs. She is also in the search of a good role in which she will be able to display her acting skills.
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