The turning point in the career of Manish Wadhwa came when he shared the stage with none other than the veteran actress Jaya Bachhan in the role of her protégé son in the stage production 'Ma Retire Hoti Hai'. This play had given his career the firm set-up it needed in the initial stages. The play had its rounds and was also widely acclaimed internationally. Following that he again got the chance to play the role of Jaya Bachhan's son in another play called 'Dr. Mukta'. His acting potential had created such waves that he also bagged a great Bollywood project by the renowned filmmaker Subhash Ghai titled 'Rahul' in such an early phase of his career. In this film he essayed the negative lead. Following that he meted out splendid performance in another film called '2nd October'. After that his fans were overwhelmed by his acting skills in another Bollywood flick 'The Forgotten Hero-Subhash Chandra Bose' by Shyam Benegal.
Besides establishing foot in the film industry in such a big way Manish Wadhwa has also wooed the audiences of the small screen and has acted in television shows like 'Kahani Jurm Si' and 'Krishna Arjun' which used to broadcasted on the popular Star Plus channel. He also acted well in some DD dailies and weeklies. At present he is not doing any plays other than that of 'Hum Le Gaye', 'Tum Reh Gaye' with another stand-up comedian actor Javed Jaffrey. In these shows again he essays a negative character. In spite of such remarkable performances he still craves to be better with each performance and remarked in a recent interview, "I just need a good role, whether positive or negative". As of now the actor has two projects in his pipeline named 'Hope' and 'Tujhko Pukare'. He would like to work in all mediums provided the role he is offered has some sensible substance in it. On the whole his fans can expect to be entertained thoroughly in the coming times with some remarkable performances from him, which will in turn see him as a matured actor.