Established in 1956, the Kurnool Medical College (KMC) is a medical school located in Kurnool, Andhra Pradesh, India. The college is an old medical institution and is also the second biggest medical college after Osmania Medical College, in Andhra Pradesh. After the foundation of the State of Andhra Pradesh in October, 1953, the newly formed Andhra Pradesh state government decided to establish a medical college in the state. The decision led to the formation of the KMC, Kurnool in July 1956. The then Finance Minister of India, Sri T. T. Krishnamachari inaugurated the KMC, Kurnool on 21st July 1956 and the college started its journey with 50 students in the MBBS course. The Andhra Pradesh government appointed Dr. C. Venkata Ramaiah, as the First Principal and Special Officer of the Kurnool Medical College (KMC).

The Government General Hospital, Kurnool is closely associated with the Kurnool Medical College (KMC), Kurnool and the hospital has been working as the teaching hospital for the students of KMC. The inauguration of the hospital and the clinical courses in KMC, Kurnool was performed on 28th January 1958 the then Health Minister of India, Sri. D. K. Karmankar. The first units in the major subjects of Medicine, Surgery and Midwifery in KMC, Kurnool were created in July 1957. In its initial period, the Kurnool Medical College was affiliated to the Sri Venkateswara University, from January 1957 and then got permanently affiliated from January 1959.

There is a NCC unit attached to the Kurnool Medical College (KMC), Kurnool and the unit started its operations in January, 1958. The college started offering Laboratory technician`s courses and laboratory attender`s courses from October 1959 and the Government also established a Regional Laboratory at this college, in the same year. The Regional Laboratory was established for serving the needs of Raayalaseema districts. There is also a well-planned Animal House with separate units for different laboratory animals in the KMC, Kurnool and it started its operations in 1961. Apart from that, there is a Central Work Shop in KMC, which started functioning from 1964, as well. The KMC, Kurnool houses two separate hostels for providing accommodation to the male and female students of the college. Apart from that, the college also houses an Assembly-cum-library hall, a clinical research block and a rural health center for the teaching of social and preventive medicine.

The Kurnool Medical College (KMC), Kurnool offers a large number of courses at the undergraduate and postgraduate levels. The postgraduate degree and diploma courses include MD in Physiology, Biochemistry, Pharmacology, Microbiology, Pathology, Forensic Medicine, SPM/Community Medicine, General Medicine, Gynecology, TBCD, STD, Pedlatrics, Anesthesia, Radiology, DCH, DCP, DMRD, and DPH. Apart from that, the college also offers MS in ENT, DLO, Ophthalmology, Anatomy, General Surgery, Orthopedics and DO. In the recent past, the Medical Council of India (MCI), New Delhi has inspected this college for recognition and starting of some super speciality course. The super speciality courses include DM in Neurology, Gastroenterology, Nephrology, Cardiology and M.Ch in Pediatrics Surgery, Neuro surgery, Plastic surgery, Cardio thoracic surgery and Urology etc. The KMC, Kurnool also started the units like Acute Medical Care (AMC) and ICCU during the year 2003, in the Government General Hospital, Kurnool.