The South Zone of the Ranji Trophy, 1967-68 was comprised of the same regular 5 teams that were playing in the tournament in the previous few editions. There was no change in the team list of the zone and the teams that participated in the tournament under this zone included the likes of Andhra, Madras, Mysore, Hyderabad and Kerala. All the teams tried their best to beat the other teams and become one of the top two teams in the zone and also to secure a birth in the knock out level of the tournament.

The South Zone league matches in the Ranji Trophy, 1967-68 was started with the match between the teams of Madras and Kerala and the match was held at Madras from 26-27 August, 1967. The Madras team played extremely well in the match and clinched a huge victory of an innings and 129 runs to earn the 8 valuable points from it and also to get a good start in the tournament. The Madras team then played against the Hyderabad team in the second match of the zone and the match took place at Madras from 02-04 September, 1967. The Madras team once again played very well in this match and defeated the Hyderabad team by a good margin of 7 wickets to earn 8 points from the match. The next match of the zone saw a clash between the teams of Hyderabad and Kerala at Trivandrum from 08-09 September, 1967. The Hyderabad team compensated its first match defeat in this match and clinched a victory with a huge margin of an innings and 140 runs. The teams earned 8 valuable points from the match, as well.

There was a clash between the teams of Mysore and Kerala in the fourth of the South Zone league matches in the Ranji Trophy, 1967-68 and the match was held at Bangalore from 16-18 September, 1967. The Mysore team played well in the match and earned 8 valuable points from it by winning with a margin of an innings and 111 runs. The next match of the South Zone involved the teams of Hyderabad and Andhra. The match was held at Hyderabad from 16-18 September, 1967 and it saw the Hyderabad team winning by an innings and 142 runs and also earning 8 points from it. The Hyderabad team appeared in the next match of the South Zone also and this time, it played against the Mysore team at Hyderabad from 23-25 September, 1967. The match was drawn during the stipulated duration and the match officials awarded the Hyderabad and Mysore teams 5 and 3 points, respectively for the match.

The seventh of the South Zone league matches in the Ranji Trophy, 1967-68 involved the two most powerful teams of the zone, Madras and Mysore and the two teams played the match at Bangalore from 14-16 October, 1967. The Madras team showed some extraordinary performances in the match and clinched a victory by a huge margin of 7 wickets to earn 8 valuable points from it. The Mysore team then played against the Andhra team at Vijayawada from 11-13 November, 1967 and the drawn match saw the Mysore team earning 5 points and Andhra earning 3 points from it. The Andhra and Madras teams met with each other in the next match of the South Zone and the match was held at Guntur from 18-20 November, 1967. The Madras team continued its good form in this match also and got a victory of an innings and 96 runs for earning 8 points from the match. The Andhra team appeared in the last of the South Zone league matches in the Ranji Trophy, 1967-68 also and this time, it played against the Kerala team at Trivandrum from 25-27 November, 1967. The winner of the match was the Andhra team with a margin of 9 wickets and the teams also earned 8 valuable points from it.