There were 5 teams played under the South Zone of the Ranji Trophy, 1963-64 and the teams included the likes of Madras, Kerala, Mysore, Hyderabad and Andhra. All the teams were representing South India in the competition and they tried their best to get a birth in the knock out level of the tournament. However, the Madras and Mysore became successful to do so from the zone.

The Madras and Kerala teams met with each other for the first of the South Zone league matches in the Ranji Trophy, 1963-64 and the match was held at Salem from 09-11 November, 1963. The Madras team started it campaign in the tournament in a positive note, as it got a victory of 193 runs in the match and earned 9 points from it. The next match saw a battle between the teams of Mysore and Kerala at Bangalore from 14-15 November, 1963. The winner of the match was the Mysore team with a margin of an innings and 198 runs and it also earned 9 points from the match. The third match of the South Zone was played between the teams of Hyderabad and Andhra at Kothagudem from 16-18 November, 1963, where the Hyderabad team won by 7 wickets for earning 8 points from it.

In the fourth of the South Zone league matches in the Ranji Trophy, 1963-64, there was a clash between the teams of Hyderabad and Mysore and the match took place at Hyderabad from 23-25 November, 1963. The Mysore team won the match by a margin of an innings and 41 runs and earned 8 points from it. The Hyderabad team appeared in the next match also and this time, it played against the Kerala team at Calicut from 01-02 December, 1963, where it earned 9 points from the match by winning by an innings and 102 runs. The sixth of the South Zone league matches in the Ranji Trophy, 1963-64 saw a battle between the teams of Andhra and Mysore at Guntur from 06-07 December, 1963. The match saw the Mysore team winning by an innings and 126 runs to earn 9 points.

The nest match of the South Zone involved the teams of Madras and Hyderabad and the match was held at Madras from 07-09 December, 1963. However, as the match was abandoned due to heavy rain, the match officials awarded 3 points each to both the teams. The two most powerful teams of the Zone, Madras and Mysore then clashed with each other at Bangalore from 14-16 December, 1963. The drawn match saw the Mysore team earning 5 points and the Madras team earning 3 points from it. Then, the teams of Kerala and Andhra met with each other at Tellicherry from 14-16 December, 1963, where the Kerala team won by 4 wickets to earn 8 points. The last of the South Zone league matches in the Ranji Trophy, 1963-64 involved the teams of Andhra and Madras and the match was played at Anantapur from 03-05 January, 1964. Madras won the match by an innings and 79 runs and also earned 8 valuable points from it.